A novel role for prolyl-hydroxylase 3 gene silencing in epithelial-to-mesenchymal-like transition
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چکیده
Approved: ____________________________________ Thesis Supervisor ____________________________________ Title and Department ____________________________________ Date A NOVEL ROLE FOR PROLYL-HYDROXYLASE 3 GENE SILENCING IN EPITHELIAL-TO-MESENCHYMAL-LIKE TRANSITION by Trenton Lane Place A thesis submitted in partial fulfillment of the requirements for the Doctor of Philosophy degree in Molecular and Cellular Biology in the Graduate College of The University of Iowa
منابع مشابه
Prolyl-4-Hydroxylase 3 (PHD3) Expression Is Downregulated during Epithelial-to-Mesenchymal Transition
Prolyl-4-hydroxylation by the intracellular prolyl-4-hydroxylase enzymes (PHD1-3) serves as a master regulator of environmental oxygen sensing. The activity of these enzymes is tightly tied to tumorigenesis, as they regulate cell metabolism and angiogenesis through their control of hypoxia-inducible factor (HIF) stability. PHD3 specifically, is gaining attention for its broad function and rapid...
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